The primary purpose of this study was to examine differences of the quantity of(1)the private help from the closest person to the patient (social support), (2) the QOL, (3) their physical conditions, and(4)anxiety, among the demographics of patients treated with hematopoietic cell transplantation. The secondary purpose was to assess whether higher degree of the social support is involved in(1)the QOL,(2)physical conditions,(3)anxiety to the future. We studied 124 pairs of adult patients after hematopoietic cell transplantation and their closest persons to analyze(1)how much the patients obtain the support,(2)questionnaire of WHO/QOL-26,(3)patients' present physical conditions,(4)anxiety for the future. The results showed that gender, age, and difference of seem cell source did not influence QOL after transplantation. The patients over 3 years after transplantation showed higher QOL, healthy conditions, and lower anxiety than patients within 3 year after transplantation. Patients who obtained more effective private supports from closest persons showed higher QOL, lower anxiety, and better conditions. These results emphasize on the importance of effective support from the closest persons/relative in patients after transplantation. More studies are needed to clarify roles of the closest person and medical staff to improve QOL of transplanted patients.