@article{oai:bunkyo.repo.nii.ac.jp:00006523,
 author = {Higuchi, Hiroki and Narita, Masaski and Sakatani, Kaoru and Narita, Naoko},
 journal = {SHONAN JOURNAL : The International Journal of the Shonan Research Institute Bunkyo University},
 month = {2012-03-01, 2014-02-21},
 note = {Recent advances in functional neuroimaging studies disclosed different and/or defective signal processing system in reading emotion in autism spectrum disorder (ASD). In addition, we reported delayed or altered response of dorsolateral prefrontal cortex to incoming stimuli in ASD patients. In present study, we measure DLPFC cerebral blood oxygenation (CBO) changes during facial expression switching task to further examine neurofunctional characteristics of ASD. Five ASD patients (IQ>70,14-46 years, 2 females) and 22 healthy volunteers (19-38years, 12 females) participated in this study. The tasks required working memory and the tasks did not require WM are presented repeatedly, and number of presented stimulus are increased up to six. In healthy controls, activation pattern was relevant with task performance rate in the switching task using facial expression, on the other hands, this tendency was not shown in ASD patients. In one ASD patient, CBO changes in channel-35 that are mainly matched to fusiform gyrus were largely increased during geometric shapes switching task, however, similar pattern was not shown in facial expression switching task. These results imply DLPFC reactivity change according to task switch might be impaired in ASD patients due to ectopic functional connectivity.},
 pages = {41--55},
 title = {Prefrontal cortical hemodynamic change due to facial expression switching task in autism spectrum disorders},
 volume = {3},
 year = {}
}