Kansei, Behavioral and Brain Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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Developmental and Regenerative Medicine, Mie University
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Department of Neurosurgery Nihon University School of Medicine
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Institute of education, Bunkyo University
内容記述
内容記述タイプ
Abstract
内容記述
Recent advances in functional neuroimaging studies disclosed different and/or defective signal processing system in reading emotion in autism spectrum disorder (ASD). In addition, we reported delayed or altered response of dorsolateral prefrontal cortex to incoming stimuli in ASD patients. In present study, we measure DLPFC cerebral blood oxygenation (CBO) changes during facial expression switching task to further examine neurofunctional characteristics of ASD. Five ASD patients (IQ>70,14-46 years, 2 females) and 22 healthy volunteers (19-38years, 12 females) participated in this study. The tasks required working memory and the tasks did not require WM are presented repeatedly, and number of presented stimulus are increased up to six. In healthy controls, activation pattern was relevant with task performance rate in the switching task using facial expression, on the other hands, this tendency was not shown in ASD patients. In one ASD patient, CBO changes in channel-35 that are mainly matched to fusiform gyrus were largely increased during geometric shapes switching task, however, similar pattern was not shown in facial expression switching task. These results imply DLPFC reactivity change according to task switch might be impaired in ASD patients due to ectopic functional connectivity.
書誌情報
SHONAN JOURNAL : The International Journal of the Shonan Research Institute Bunkyo University
